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 Personal Information |
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- Title : Processor
- Position :
- Tel: 10-51684348
- E-mail: jqhuang@bjtu.edu.cn
- Present Address: School of Science, Beijing Jiaotong University,No 3. Shangyuancun, Haidian District, Beijing,P.R.China, 100044
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| Education |
- 1997 Ph. D., Tongji Medical College, Huazhong University of Science & Technology. Hubei, China
- 1993 M.S. Med, Tongji Medical College, Huazhong University of Science & Technology. Hubei, China
- 1986 M.D., Henan University School of Medicine, Henan, China
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| Research Interest |
• Genetic and epigenetic alterations in the diagnosis of cancer and inflammation.
• Interplay between epigenetic and genetic events in regulating of gene expression |
| Funding |
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| Major Publication |
- Pan Y*, Huang J*, (Co-first author) Xing R, Yin X, Cui J, Li W, Yu J, Lu Y. Metallothionein 2A inhibits NF-κB pathway activation and predicts clinical outcome segregated with TNM stage in gastric cancer patients following radical resection. J Transl Med. 2013; 19;11:173.
- Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y. IL-7Rα deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis. Cell Death Differ. 2012;19:1139-51.
- Hamano R, Huang J, Yoshimura T, Oppenheim JJ, Chen X. TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40. Eur J Immunol. 2011; 41:2010-20.
- Tao Y, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K. Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences. Proc Natl Acad Sci U S A. 2011;108:5626-31.
- Zhu G, Augustine MM, Azuma T, Luo L, Yao S, Anand S, Rietz AC, Huang J, Xu H, Flies AS, Flies SJ, Tamada K, Colonna M, van Deursen JM, Chen L. B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood. 2009;113:1759-67.
- Huang J, Chen K, Huang J, Gong W, Dunlop NM, Howard OM, Bian X, Gao Y, Wang JM. Regulation of the leucocyte chemoattractant receptor FPR in glioblastomacells by cell differentiation. Carcinogenesis. 2009; 30:348-55.
- Jiang Q, Huang J, Li WQ, Cavinato T, Keller JR, Durum SK. Role of theintracellular domain of IL-7 receptor in T cell development. J Immunol. 2007; 178:228-34.
- Wang LH, Yang XY, Zhang X, An P, Kim HJ, Huang J, Clarke R, Osborne CK, Inman JK, Appella E, Farrar WL. Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer. Cancer Cell. 2006;10:487-99.
- Huang J, Fan T, Yan Q, Zhu H, Fox S, Issaq HJ, Best L, Gangi L, Munroe D, Muegge K. Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Res. 2004; 32(17):5019-28.
- Wang LH, Yang XY, Zhang X, Huang J, Hou J, Li J, Xiong H, Mihalic K, Zhu H, Xiao W, Farrar WL. Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. Immunity. 2004; 20:205-18.
- Yan Q*, Huang J*, (Co-first author) Fan T, Zhu H, Muegge K. Lsh, a modulator of CpG methylation, is crucial for normal histone methylation. EMBO J. 2003; 22:5154-62.
- Fan T, Yan Q, Huang J, Austin S, Cho E, Ferris D, Muegge K. Lsh-deficient murine embryonic fibroblasts show reduced proliferation with signs of abnormal mitosis. Cancer Res. 2003; 63:4677-83.
- Khaled AR, Li WQ, Huang J, Fry TJ, Khaled AS, Mackall CL, Muegge K, Young HA, Durum SK. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity. 2002; 17:561-73.
- Huang J, Durum SK, Muegge K. Cutting edge: histone acetylation and recombination at the TCR gamma locus follows IL-7 induction. J Immunol. 2001; 167:6073-7.
- Huang J, Muegge K. Control of chromatin accessibility for V(D)J recombination by interleukin-7. J Leukoc Biol. 2001; 69:907-11.
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| Awards＆Honors |
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